Buprenorphine: a controlled clinical trial in the treatment of opioid dependence.

摘要: Clinical trials carried out to compare methadone and buprenorphine in the treatment of opioid dependence have generally employed an alcoholic solution buprenorphine, which has a bioavailability superior that tablets. Since product available for large scale use is tablet form, one intended verify efficacy this formulation. In multicentre randomised controlled double blind study, 72 dependent patients were assigned with (8 mg/day) or (60 period 6 months. The two compounds did not show any significant difference regard urinalyses: average percentage analyses proving negative was 60.4% 65.5% those methadone. With retention, non-significant trend favour observed. Patients completing trial improved significantly terms psychosocial adjustment global functioning, as ascertained by DSM-IV-GAF symptom checklist-90 (SCL-90) scales, independent group. Finally, case who dropped differed from stayed, higher level psychopathological symptoms, lower functioning. results study further support utility dependence.