Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

摘要: Purpose: To explore the value of systemic inflammatory markers as independent prognostic factors and extent these improve classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy. Methods: We studied such circulating white blood cell count its components well that combined to form inflammation-based scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte (PLR), Index (PI) Nutritional (PNI)) in 384 first-line Univariate multivariate analyses were performed examine impact on overall survival (OS). Results: analysis revealed an elevated cell, neutrophil and/or platelet count, a decreased lymphocyte low serum albumin concentration, high CRP NLR/PLR , GPS, PI, PNI significant predictors shorter OS. Multivariate demonstrated only (HR 3.696, p=0.003) higher GPS 1.621, p=0.01) poor Conclusion: This study pretreatment be OS GC treated Upon validation data studies, stratification using future clinical trials is recommended.