Dissociation of rugose-dependent short-term memory component from memory consolidation in Drosophila.

摘要: Extensive investigations show several molecular and neuroanatomical mechanisms underlying short-lived long-lasting memory in Drosophila. At the level, genetic pathway of formation, which was obtained through mutant research, seems to occur sequentially. So far, studies Drosophila mutants appear support idea that defective short-term (STM) are always associated with long-term (LTM) impairment. distinct traces partially independently distributed. However, whether phase dissociation also exists at level remains unclear. Here, we report on separation STM consolidated dissection rugose mutants. Mutants gene, encodes an evolutionarily conserved A-kinase anchor protein, immediate defects as assayed aversive olfactory conditioning. Intriguingly, two well-defined components, anesthesia-resistant protein synthesis-dependent LTM, both normal spite after 10-session massed spaced training. Moreover, genetically interacts cyclic AMP-protein kinase A signaling during formation. Considering our previous study AKAP Yu specifically participates LTM these results suggest there a AKAPs