The relationship of airways responsiveness to cold air, cigarette smoking, and atopy to respiratory symptoms and pulmonary function in adults

摘要: The response to eucapnic hyperventilation with subfreezing air was studied in a population based sample of 171 adults, all whom also completed respiratory questionnaire, spirometry, and skin testing. A positive the cold challenge defined as [initial FEV1-post-challenge FEV1)/initial FVC) X 100) greater than or equal 9%. Cigarette smoking response: 12 128 current ex-smokers (9.4%) versus 1 43 nonsmokers (2.3%) (p = 0.095). Among ex-smokers, significantly associated asthma 0.046). Using logistic regression model, both were significant predictors presence "persistent wheeze" asthma. test any 4 environmental antigens used (ragweed, housedust, trees, grasses) cigarette 0.018) hay fever 0.003 among ex-smokers) but not wheezing Though statistically significant, responders had lower percentage reactivity nonreactors. findings this cross-sectional analysis suggest that airways responsiveness are important Furthermore, data airway hyperresponsiveness atopy independent traits. However, these traits smoking, common exposure.