The Art of Meeting Palladium Specifications in Active Pharmaceutical Ingredients Produced by Pd-Catalyzed Reactions

摘要: The use of palladium-derived catalysts in the synthesis fine chemicals, pharmaceutical inter- mediates and active ingredients (APIs) has become quite common last few dec- ades. number palladium-catalyzed synthetic re- actions (both achiral chiral) available to chemists provided access more complex structures fewer steps with less waste, due catalytic nature many methods. An unfortunate side effect using palladium is potential for palladi- um-containing impurities remain desired compound after isolation. This an especially signifi- cant problem industry since there a low limit heavy metal allowed drug substance. Therefore, various methods removing from organic com- pounds interest have been devel- oped. review will provide survey publish- ed but not meant be inclusive all pub- lished material this area research.