Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape
作者： Lisbeth Ilium , S.S. Davis , C.G. Wilson , N.W. Thomas , M. Frier
DOI: 10.1016/0378-5173(82)90113-2
关键词: Mononuclear phagocyte system 、 Deposition (aerosol physics) 、 Cellulose 、 Particle size 、 Gamma scintigraphy 、 Blood clearance 、 Polystyrene 、 Chromatography 、 Colloidal particle 、 Chemistry
摘要: The blood clearance and organ deposition of polystyrene and cellulose (DEAE) particles have been studied in the rabbit using labelled material and the technique of gamma scintigraphy in order to investigate the importance of particle size, shape and nature. Small (1.27 μm diameter) polystyrene microspheres were taken up by the reticuloendothelial system of the liver, while large polystyrene particles (15.8 μm diameter) were mechanically filtered by capillary beds of the lungs. Cellulose microspheres and fibres were also taken up …
sci-hub.se 参考文章(14)
P. A. Myers, D. J. Wilkins, Studies on the relationship between the electrophoretic properties of colloids and their blood clearance and organ distribution in the rat. British journal of experimental pathology. ,vol. 47, pp. 568- 576 ,(1966)
S.L. Yang, W.C. Klingensmith, H.N. Wagner, Lung uptake of Tc-99m sulfur colloid in liver and spleen imaging. The Journal of Nuclear Medicine. ,vol. 19, pp. 31- ,(1978)
George V. Taplin, George V. Taplin, Harold Kade, Harold Kade, Orsell M. Meredith, Orsell M. Meredith, The radioactive (I131 tagged) rose bengal uptake-excretion test for liver function using external gamma-ray scintillation counting techniques. Journal of Laboratory and Clinical Medicine. ,vol. 45, pp. 665- 678 ,(1955) , 10.5555/URI:PII:0022214355900238
Yeon Huh, G. Wm. Donaldson, F. J. Johnston, A Radiation-Induced Bonding of Iodine at the Surface of Uniform Polystyrene Particles Radiation Research. ,vol. 60, pp. 42- 53 ,(1974) , 10.2307/3574004
HG Schroeder, Guy H Simmons, Patrick P Deluca, None, Distribution of Radiolabeled Subvisible Microspheres after Intravenous Administration to Beagle Dogs Journal of Pharmaceutical Sciences. ,vol. 67, pp. 504- 507 ,(1978) , 10.1002/JPS.2600670417
Tapan K. Chaudhuri, Titus C. Evans, Tuhin K. Chaudhuri, Autoradiographic Studies of Distribution in the Liver of198Au and99mTc-Sulfur Colloids Radiology. ,vol. 109, pp. 633- 637 ,(1973) , 10.1148/109.3.633
Lisbeth Ilium, Stanley S. Davis, Cellulose microspheres as a sustained release system for parenteral administration International Journal of Pharmaceutics. ,vol. 11, pp. 323- 327 ,(1982) , 10.1016/0378-5173(82)90082-5
Motoko Kanke, Guy H Simmons, Daniel L Weiss, Brack A Bivins, Patrick P Deluca, None, Clearance of 141Ce‐labeled microspheres from blood and distribution in specific organs following intravenous and intraarterial administration in beagle dogs Journal of Pharmaceutical Sciences. ,vol. 69, pp. 755- 762 ,(1980) , 10.1002/JPS.2600690703
Tetsuro Kato, Arterial Chemoembolization With Microencapsulated Anticancer Drug JAMA. ,vol. 245, pp. 1123- 1127 ,(1981) , 10.1001/JAMA.1981.03310360015014
Ronald Purkiss, Effects and distribution of intravenously administered cellulose particles in mice. Journal of Pharmacy and Pharmacology. ,vol. 27, pp. 290- 292 ,(2011) , 10.1111/J.2042-7158.1975.TB10704.X