miR-409 Inhibits Human Non-Small-Cell Lung Cancer Progression by Directly Targeting SPIN1.

摘要: Lung cancers, the leading cause of cancer mortality worldwide, are characterized by a high metastatic potential. Growing evidence reveals that Spindlin 1 (SPIN1) is involved in tumor progression and carcinogenesis. However, role SPIN1 non-small-cell lung (NSCLC) molecular mechanisms underlying human NSCLC remain undetermined. Here we examined function found expression was closely correlated with overall survival poor prognosis patients. Aberrant regulation microRNAs (miRNAs) has an important progression. We revealed miR-409 inhibits binding directly to 3′ UTR using dual-luciferase reporter assays. Overexpression significantly suppressed cell migration, growth, proliferation inhibiting in vitro in vivo. overexpression miR-409-transfected cells effectively rescued suppression regulated miR-409. regulates PI3K/AKT (protein kinase B) pathway NSCLC. Moreover, clinical data showed patients levels experienced better survival. also negatively associated expression. Taken together, these findings highlight miR-409/SPIN1 axis useful pleiotropic regulatory network could predict potential early, indicating possibility might be attractive prognostic markers for treating