The remarkable similarity between the acid-base properties of ISFETs and proteins and the consequences for the design of ISFET biosensors
作者： P. Bergveld , R.E.G. van Hal , J.C.T. Eijkel
DOI: 10.1016/0956-5663(95)96887-5
关键词: Titration 、 Base (chemistry) 、 Analytical chemistry 、 Nanotechnology 、 Protein molecules 、 Characterization (materials science) 、 ISFET 、 Biosensor 、 Capacitance 、 Oxide 、 Chemistry
摘要: Studying the acid-base properties of protein molecules led us to reconsider operational mechanism ISFETs. Based on site-dissociation model, applied amphoteric metal oxide gate materials used in ISFETs, sensitivity ISFETs is described terms intrinsic buffer capacity surface, βs, and electrical surface capacitance, Cs. The ISFET towards changes bulk pH fully by ratio βs/Cs. Practical measurements support this theoretical approach. The new approach description analogous classical molecules. titration proteins also determined ration between double layer capacitance. In addition amazing conclusion that surfaces behave a similar way with respect their properties, further conclusions are drawn possibility characterization means dynamic covered Design rules given for type biosensors, based understanding behaviour both sensor parts.
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