2,2'-Dichlorodiethyl sulfide (sulfur mustard) decreases NAD+ levels in human leukocytes.
作者： Henry Louis Meier , Clark L. Gross , Bruno Papirmeister
DOI: 10.1016/0378-4274(87)90263-3
关键词: NAD+ kinase 、 Sulfur mustard 、 Polymerase 、 Dna breaks 、 Cell type 、 DNA 、 DNA Alkylation 、 Sulfide 、 Biochemistry 、 Chemistry
摘要: Abstract 2,2′-Dichlorodiethyl sulfide (sulfur mustard, HD) extensively alkylates DNA in a concentrationdependent manner many cell types. We have proposed biochemical hypothesis that explains HDinduced injury by linking alkylation and breaks with activation of poly(ADP-ribose) polymerase, resulting depletion cellular NAD + . This was tested treating human leukocytes HD to determine whether occurred as predicted. These cells demonstrated decrease levels which dependent on both concentration time after exposure. Inhibitors polymerase or substrates for synthesis were able prevent the HD-induced decrease.
sci-hub.se 参考文章(30)
Tomas Lindahl, DNA glycosylases, endonucleases for apurinic/apyrimidinic sites, and base excision-repair. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 22, pp. 135- 192 ,(1979) , 10.1016/S0079-6603(08)60800-4
P Brookes, PD Lawley, The reaction of mono- and di-functional alkylating agents with nucleic acids Biochemical Journal. ,vol. 80, pp. 496- 503 ,(1961) , 10.1042/BJ0800496
David B. Ludlum, Bruno Papirmeister, DNA Modification by Sulfur Mustards and Nitrosoureas and Repair of these Lesions Basic life sciences. ,vol. 38, pp. 119- 125 ,(1986) , 10.1007/978-1-4615-9462-8_12
Kunihiro Ueda, Osamu Hayaishi, Adp-Ribosylation Reactions: Biology and Medicine ,(1982)
I. M. Roitt, The inhibition of carbohydrate metabolism in ascites-tumour cells by ethyleneimines Biochemical Journal. ,vol. 63, pp. 300- 307 ,(1956) , 10.1042/BJ0630300
Lawrence M. Lichtenstein, The Immediate Allergic Response: in Vitro Separation of Antigen Activation, Decay and Histamine Release Journal of Immunology. ,vol. 107, pp. 1122- 1130 ,(1971)
David L. Busbee, Virgil R. Mitchell, Patrick W. Rankin, Myron K. Jacobson, Reduction of Nicotinamide Adenine Dinucleotide Levels by Ultimate Carcinogens in Human Lymphocytes Cancer Research. ,vol. 40, pp. 1803- 1807 ,(1980)
D W MacGlashan, L M Lichtenstein, The transition from specific to nonspecific desensitization in human basophils. Journal of Immunology. ,vol. 127, pp. 2410- 2414 ,(1981)
Elaine L. Jacobson, Myron K. Jacobson, Pyridine nucleotide levels as a function of growth in normal and transformed 3t3 cells. Archives of Biochemistry and Biophysics. ,vol. 175, pp. 627- 634 ,(1976) , 10.1016/0003-9861(76)90553-1
E.S. Guzman Barron, J. Meyer, Zelma Baker Miller, The Metabolism of Skin. Effect of Vesicant Agents1 Journal of Investigative Dermatology. ,vol. 11, pp. 97- 118 ,(1948) , 10.1038/JID.1948.75