Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT.
作者： Scott T. Grafton , Ronald J. Voll , Michael G. Byas-Smith , Tracy L. Faber , J. Douglas Bremner
DOI:
关键词: Putamen 、 Caudate nucleus 、 Radioligand 、 Serotonin transporter 、 Dopamine transporter 、 Cerebellum 、 Arterial blood 、 Medicine 、 In vivo 、 Nuclear medicine
摘要: The aim of this study was to do an initial assessment of the usefulness of 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-18F-fluoroethyl) nortropane (18F-FECNT) PET scanning in …
参考文章(34)
M Goldstein, DB Calne, RL Elton, CD Marsden, S Fahn, Recent Developments in Parkinson's Disease ,(1986)
Y Zea-Ponce, R B Innis, J P Seibyl, D S Charney, K Marek, P B Hoffer, K Sheff, C H van Dyck, S Zoghbi, R M Baldwin, Test/retest reproducibility of iodine-123-betaCIT SPECT brain measurement of dopamine transporters in Parkinson's patients. The Journal of Nuclear Medicine. ,vol. 38, pp. 1453- 1459 ,(1997)
Elina Nurmi, Jörgen Bergman, Olli Eskola, Olof Solin, Susanna M. Hinkka, Pirkko Sonninen, Juha O. Rinne, Reproducibility and effect of levodopa on dopamine transporter function measurements: a [18F]CFT PET study. Journal of Cerebral Blood Flow and Metabolism. ,vol. 20, pp. 1604- 1609 ,(2000) , 10.1097/00004647-200011000-00010
Klaus Wienhard, Lars Eriksson, Sylke Grootoonk, Mike Casey, Uwe Pietrzyk, Wolf-Dieter Heiss, Performance evaluation of the positron scanner ECAT EXACT. Journal of Computer Assisted Tomography. ,vol. 16, pp. 804- 813 ,(1992) , 10.1097/00004728-199209000-00024
J. P. Seibyl, K. L. Marchek, D. Quinlan, K. Sheff, S. Zoghbi, Y. Zea-Ponce, R. M. Baldwin, B. Fussell, E. O. Smith, D. S. Charney, P. B. Hoffer, R. B. Innis, Decreased single‐photon emission computed tomographic {123I}β‐CIT striatal uptake correlates with symptom severity in parkinson's disease Annals of Neurology. ,vol. 38, pp. 589- 598 ,(1995) , 10.1002/ANA.410380407
Aki Laakso, J�rgen Bergman, Merja Haaparanta, Harry Vilkman, Olof Solin, Jarmo Hietala, [18F]CFT [(18F)WIN 35,428], a radioligand to study the dopamine transporter with PET: characterization in human subjects. Synapse. ,vol. 28, pp. 244- 250 ,(1998) , 10.1002/(SICI)1098-2396(199803)28:3<244::AID-SYN7>3.0.CO;2-A
Kang-Ping Lin, Sung-Cheng Huang, Dan-Chu Yu, William Melega, Jorge R Barrio, Michael E Phelps, Automated image registration for FDOPA PET studies Physics in Medicine and Biology. ,vol. 41, pp. 2775- 2788 ,(1996) , 10.1088/0031-9155/41/12/014
Mark M Goodman, Clinton D Kilts, Robert Keil, Bing Shi, Laurent Martarello, Dongxia Xing, John Votaw, Timothy D Ely, Philip Lambert, Michael J Owens, Vernon M Camp, Eugene Malveaux, John M Hoffman, 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Nuclear Medicine and Biology. ,vol. 27, pp. 1- 12 ,(2000) , 10.1016/S0969-8051(99)00080-3
David Stout, Andrej Petric, N. Satyamurthy, Quan Nguyen, Sung-Cheng Huang, Mohammad Namavari, Jorge R. Barrio, 2β-carbomethoxy-3β-(4- and 2-[18F]fluoromethylphenyl)tropanes : Specific probes for in vivo quantification of central dopamine transporter sites Nuclear Medicine and Biology. ,vol. 26, pp. 897- 903 ,(1999) , 10.1016/S0969-8051(99)00073-6
Yasushi Ito, Masahiro Fujita, Shoichi Shimada, Yoshiyuki Watanabe, Tomoya Okada, Hideo Kusuoka, Masaya Tohyama, Tsunehiko Nishimura, Comparison between the decrease of dopamine transporter and that of L-DOPA uptake for detection of early to advanced stage of Parkinson's disease in animal models. Synapse. ,vol. 31, pp. 178- 185 ,(1999) , 10.1002/(SICI)1098-2396(19990301)31:3<178::AID-SYN2>3.0.CO;2-M