Longitudinal trends in use of targeted therapies for treatment of malignant neoplasms of the eye: a population-based study in Taiwan

作者: Jason C Hsu , Luis A Gonzalez-Gonzalez , Vicky H Lu , Christine Y Lu

DOI: 10.1136/BMJOPEN-2015-010706

关键词: Evidence-based practiceMarket shareEye neoplasmIntensive care medicineRetrospective cohort studyMedicineHealth economicsMedical prescriptionEpidemiologyHealth policy

摘要: Objectives This study examined the recent trend in use and costs of antineoplastic agents for treatment eye malignancies Taiwan from 2009 to 2012. We also forecasted targeted therapies up including year 2016 based on current patterns. Design Retrospective observational focusing usage malignancy. Setting The monthly claims data malignancy-related were retrieved Taiwan's National Health Insurance Research Database (2009–2012). Main outcome measures calculated number prescriptions each class medications, analysed their time trends. In addition, using a series design with ARIMA models, we estimated market share by prescription volume proportion 2016. Results grew 1.56% 9.98% 2012 among all agents, rose 15.12% 58.88% Especially, protein kinase inhibitors 25.62% 45.28% between 2010 predicted reach 27.33% 91.39% fourth quarter 2016, respectively. Conclusions is first that Taiwan. Our findings indicate that, compared other classes drugs, are having more relevant strategies Taiwan, due high they likely cause great economic burden.

参考文章(45)
Wayne D Hall, Robyn Ward, Winston S Liauw, Jo-anne E Brien, Christine Y Lu, None, Tailoring access to high cost, genetically targeted drugs. The Medical Journal of Australia. ,vol. 182, pp. 607- 608 ,(2005) , 10.5694/J.1326-5377.2005.TB06844.X
J A Shields, A D Singh, C L Shields, P De Potter, Diagnosis and treatment of uveal melanoma. Seminars in Oncology. ,vol. 23, pp. 763- 767 ,(1996)
W Lipworth, I Kerridge, N Ghinea, If we don’t talk about value, cancer drugs will become terminal for health systems The Conversation. ,(2015)
C. Y. Lu, P. Srasuebkul, A. K. Drew, R. L. Ward, S.-A. Pearson, Positive spillover effects of prescribing requirements: increased cardiac testing in patients treated with trastuzumab for HER2+ metastatic breast cancer. Internal Medicine Journal. ,vol. 42, pp. 1229- 1235 ,(2012) , 10.1111/J.1445-5994.2011.02604.X
Terence C. Mills, Time series techniques for economists ,(1990)
Jason C. Hsu, Dennis Ross-Degnan, Anita K. Wagner, Fang Zhang, Christine Y. Lu, How Did Multiple FDA Actions Affect the Utilization and Reimbursed Costs of Thiazolidinediones in US Medicaid Clinical Therapeutics. ,vol. 37, pp. 1420- 1432 ,(2015) , 10.1016/J.CLINTHERA.2015.04.006
Cancer Incidence and Mortality Trends Among Whites in the United States, 1947–84 Journal of the National Cancer Institute. ,vol. 79, pp. 701- 770 ,(1987) , 10.1093/JNCI/79.4.701
Jason C. Hsu, Christine Y. Lu, Anita K. Wagner, K. Arnold Chan, Mei-Shu Lai, Dennis Ross-Degnan, Impacts of drug reimbursement reductions on utilization and expenditures of oral antidiabetic medications in Taiwan: an interrupted time series study. Health Policy. ,vol. 116, pp. 196- 205 ,(2014) , 10.1016/J.HEALTHPOL.2013.11.005
Y-H Chen, H-Y Lin, W-M Hsu, S-M Lee, C-Y Cheng, Retinoblastoma in Taiwan: incidence and survival characteristics from 1979 to 2003. Eye. ,vol. 24, pp. 318- 322 ,(2010) , 10.1038/EYE.2009.80