Predicted amplitude and form of action potentials recorded from unmyelinated nerve fibres

摘要: Abstract The effects of changes in various membrane properties (rate constants, ionic conductances, capacitance and resting potential) on the form conduction velocity action potentials have been calculated using Hodgkin-Huxley plus cable equations. relative different potential may be useful determining mechanisms underlying differences which found experimentally. Methods recording from a nerve fibre restricted extracellular space are considered give measures intracellular (monophasic recording), its first difference (diphasic second (triphasic recording) or third (quadraphasic recording). In addition to factor depending (or differences) formulae for all three methods contain an identical geometric factor. triphasic quadraphasic not analysed detail previously, though common experimental use. Also computed time is effect passive fibres trunk amplitude recorded extracellularly active fibre. For long lengths space, increases as square diameter methods. Fibre can peak potentials, often estimated this way more accurately than measurement velocity. short nerve, also vary systematically with diameter, but depend method, interelectrode spacing length space.