Parameter space boundaries for unidentifiable compartmental models.

作者: Sandor Vajda , Joseph J. Distefano , Keith R. Godfrey , John Fagarasan

DOI: 10.1016/0025-5564(89)90042-4

关键词: MathematicsPoint (geometry)Estimation theoryCalculusBoundary (topology)Parameter spaceParameter identification problemApplied mathematicsBounded functionBounding overwatchInterval arithmetic

摘要: Methods for dealing with unidentifiable compartmental models are first reviewed, emphasizing the parameter interval analysis and exhaustive modeling approaches. More general methods presented generating set of all nonnegative solutions that localize parameters within bounded regions space extend previously published bounding strategies. Each point these is an equivalent solution identification problem. If a on boundary selected, at least one vanishes submodel obtained. This property shows close relationship between

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