Silibinin Administration Improves Hepatic Failure Due to Extensive Liver Infiltration in a Breast Cancer Patient

摘要: Background: Silibinin exerts hepatoprotective, anti-inflammatory and anti-fibrotic effects. Several pre- clinical studies have shown anti-tumoral activity of silibinin in breast cancer cell lines. Case Report: We present the case a heavily pre-treated patient with extensive liver infiltration. The presented progressive failure despite several chemotherapy treatments, including paclitaxel, capecitabine vinorelbine. After four cycles fourth-line treatment consisting carboplatin gemcitabine, patient's blood test results deteriorated to life-threatening levels. compassionate use Legasil ® , new commercially available nutraceutical product containing formulation, was offered according article 37 2013 Declaration Helsinki. initiation, improvement, which permitted continue palliative chemotherapy. Conclusion: This is first report benefit administration patient.