Immunological Phenomena in Rheumatoid Arthritis

摘要: Publisher Summary This chapter explores the immunological phenomena in rheumatoid arthritis. One of most characteristic serological features is presence (or “antiglobulin”) factors which are antibodies directed against host's IgG. Classically these were recognized to be IgM antiglobulins detectable by agglutination (say) sheep cells coated with rabbit antibody or latex particles bearing human IgG, but they can also detected other immunoglobulin classes. Because their readiness bind IgG altered heat aggregation formation an immune complex. The sera from arthritis showed reactivity a number specificities on molecule, amongst considerations has helped define genetic marker systems such as Gm and Inv. A reaction native distinct undoubtedly shown as, for example, 22S IgM–IgG complexes patients' sera, inhibition reactions demonstration some factor hidden complexing autologous