The Role of the Immune System in Fracture Healing

摘要: Abstract While developmental processes usually terminate when animals reach maturity, morphogenetic may be reinitiated in specific tissues as a consequence of injury. Fracture healing and bone repair are among the unique postnatal tissue regeneration that believed to mirror ontological events take place during embryological development skeleton. Many genes expressed preferentially embryonic stem cells initiation activation pathways skeletal also fracture callus tissues. It is generally it recapitulation these allows repaired without scar tissue, ultimately leads damaged its preinjury structure. This contrast soft heals typically with some degree fibroblastic formation. The interplay number different (vascular, hematopoietic, skeletal, neural) essential for unimpeded bone. Appropriate passage through this regenerative cascade dependent on proper orchestration paracrine, autocrine, systemic signaling appropriate complement needed regenerate organ. In context process both innate adaptive immune regulatory factors contribute process, recruitment cells, control cell differentiation, remodeling regenerated injured element’s original form function.