Origin and evolution of the Trk family of neurotrophic receptors.

摘要: Among the numerous tyrosine kinase receptors, those belonging to Trk family are distinctively involved in development of complex traits within vertebrate nervous system. Until recently, lack a proper Nt/Trk system invertebrates has lead belief that they were innovation. Recent data, however, have challenged field, and proved bona fide receptors do exist invertebrates. Here, we review discuss evolutionary history receptor family, draw comprehensive scenario situates origin signalling prior vertebrates. Probably, ProtoTrk was invented by means domain exon shuffling from pieces ancient genes, generating unique combination domains found extant receptors. It is suggestive propose subtle protein mutations, gene duplications, co-options particular territories primitive instrumental