Docetaxel (Taxotere® Trihydrate) Forms: Crystal Structure Determination from XRPD & XRSCD Data

摘要: Docetaxel (form A), a stoichiometric hydrate containing three water molecules per molecule of drug substance (Taxotere®), is thermodynamically stable under ambient conditions pressure, temperature and relative humidity. In order to gain better understanding docetaxel system at the atomic scale structural study was performed. Due strong anisotropy crystals (thin plates), crystal structure (29 degrees freedom) solved refined using high resolution XRPD data applying an ab initio direct space method. parallel, in-depth growth carried out until single suitable for XRSCD were obtained: surprisingly, new polymorph docetaxel, called form B, isolated.