Importance of vitreous liquefaction in age-related cataract.
作者： George J. Harocopos , Ying-Bo Shui , Megan McKinnon , Nancy M. Holekamp , Mae O. Gordon
DOI: 10.1167/IOVS.03-0820
关键词: Ophthalmology 、 Eye disease 、 Surgery 、 Liquefaction 、 Vitreous liquefaction 、 Eye bank 、 Cataracts 、 Medicine 、 Age-related cataract 、 Nuclear sclerosis 、 Vitrectomy
摘要: PURPOSE. Vitrectomy is associated with the rapid progression of nuclear cataracts. This study was conducted to test hypothesis that age-related liquefaction vitreous gel may also be lens opacification. METHODS. Lenses from eye bank eyes were graded for nuclear, cortical, and posterior subcapsular opacities, amount liquid measured. RESULTS. Nuclear sclerosis (NS) grade, percent liquefaction, age all correlated highly (P 0.0001). After adjustment made age, correlation between NS 0.37 0.0001), after 0.57 stratified into groups, found highest in donors aged 51 70. Cortical opacities increased but scores these cataract types did not significantly correlate liquefaction. CONCLUSIONS. Loss during aging increases risk Preservation or replacement protect patients cataract. (Invest Ophthalmol Vis Sci. 2004;45:77‐ 85) DOI:10.1167/iovs.030820
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researchgate.net 参考文章(71)
Jun Akiba, Norio Ueno, Bireswar Chakrabarti, Age-related changes in the molecular properties of vitreous collagen Current Eye Research. ,vol. 12, pp. 951- 954 ,(1993) , 10.3109/02713689309020402
Anne Vaughan-Thomas, Victor C. Duance, Sophie J. Gilbert, Elevated levels of proteolytic enzymes in the aging human vitreous Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 3299- 3304 ,(2000)
Emanuel Rosen, Vitreous detachment associated with nuclear sclerosis. American Journal of Ophthalmology. ,vol. 54, pp. 837- 841 ,(1962) , 10.1016/0002-9394(62)94171-5
Stephen S. Lane, RISK FACTORS ASSOCIATED WITH AGE-RELATED NUCLEAR CORTICAL CATARACT: A Case-Control Study in the Age-Related Eye Disease Study, AREDS Report No. 5 Evidence-based Eye Care. ,vol. 3, pp. 78- 79 ,(2002) , 10.1097/00132578-200204000-00008
Alan M. Roth, Robert Y. Foos, A System for the Macroexamination of Eyes in the Laboratory American Journal of Clinical Pathology. ,vol. 59, pp. 674- 683 ,(1973) , 10.1093/AJCP/59.5.674
Hugh R. Taylor, Sheila K. West, Frank S. Rosenthal, Beatriz Muñoz, Henry S. Newland, Helen Abbey, Edward A. Emmett, Effect of Ultraviolet Radiation on Cataract Formation New England Journal of Medicine. ,vol. 319, pp. 1429- 1433 ,(1988) , 10.1056/NEJM198812013192201
Qing-Lin Huang, J. S. Zigler, M. F. Lou, Effect of opacification and pigmentation on human lens protein thiol/disulfide and solubility. Current Eye Research. ,vol. 8, pp. 883- 890 ,(1989)
Y Le Mer, B Ameline, F Campinchi, J Haut, G Van Effenterre, S Quesnot, [Is vitrectomy cataractogenic? Study of changes of the crystalline lens after surgery of retinal detachment] Journal Francais D Ophtalmologie. ,vol. 15, pp. 449- 454 ,(1992)
Kitagawa K, Ogino N, Ogura Y, [Prospective longitudinal studies on lens changes after vitrectomy--quantitative assessment by fluorophotometry and refractometry]. Japanese Journal of Ophthalmology. ,vol. 97, pp. 627- 631 ,(1993)
H Helbig, J P Hinz, M H Foerster, U Kellner, Oxygen in the anterior chamber of the human eye. German journal of ophthalmology. ,vol. 2, pp. 161- 164 ,(1993)