An amphiphilic PEG-b-PFPE-b-PEG triblock copolymer: synthesis by CuAAC click chemistry and self-assembly in water
作者： Gérald Lopez , Marc Guerre , Judith Schmidt , Yeshayahu Talmon , Vincent Ladmiral
DOI: 10.1039/C5PY01621E
关键词: Click chemistry 、 Nuclear magnetic resonance spectroscopy 、 PEG ratio 、 Polymer chemistry 、 Copolymer 、 Dynamic light scattering 、 Critical micelle concentration 、 Materials science 、 Micelle 、 Amphiphile
摘要: A new PEG2000-b-PFPE1200-b-PEG2000 amphiphilic triblock copolymer was synthesized by copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC). The microstructure of this ABA unequivocally characterized NMR spectroscopy. Diffusion-ordered spectroscopy (DOSY) experiment revealed that 1H resonances belonging to PEG and PFPE are aligned on the same horizontal line, thus implying all these signals due macromolecule whose diffusion coefficient is lower than homopolymers. Thanks its semi-fluorinated backbone bearing robust triazole rings, exhibits good thermal stability with no significant weight loss until 275 °C under air. This undergoes self-assembly into micelles (D = 10–20 nm) in aqueous solution as confirmed from cryogenic-temperature transmission electron microscopy, DOSY D2O, dynamic light scattering. critical micelle concentration determined pyrene fluorescence assay, found be 0.1 mg mL−1.
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