Alternative RNA splicing and cancer

作者: Sali Liu , Chonghui Cheng

DOI: 10.1002/WRNA.1178

关键词: RNAAlternative splicingComputational biologyBiologyHuman genomeGene isoformMessenger RNAGeneticsMechanism (biology)GeneRegulation of gene expression

摘要: … to alternative splicing regulation. For example, the Bcl-x gene is alternatively spliced to … One of the key features that enable tumor cells to overcome senescence and cell death is …

参考文章(226)
G Papoff, G Ruberti, I Cascino, G Fiucci, Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. Journal of Immunology. ,vol. 154, pp. 2706- 2713 ,(1995)
Kaori Fujita, Abdul M. Mondal, Izumi Horikawa, Giang H. Nguyen, Kensuke Kumamoto, Jane J. Sohn, Elise D. Bowman, Ewy A. Mathe, Aaron J. Schetter, Sharon R. Pine, Helen Ji, Borivoj Vojtesek, Jean-Christophe Bourdon, David P. Lane, Curtis C. Harris, p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence Nature Cell Biology. ,vol. 11, pp. 1135- 1142 ,(2009) , 10.1038/NCB1928
T Noguchi, H Inoue, T Tanaka, The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. Journal of Biological Chemistry. ,vol. 261, pp. 13807- 13812 ,(1986) , 10.1016/S0021-9258(18)67091-7
Dimitrios Mougiakakos, Aniruddha Choudhury, Alvaro Lladser, Rolf Kiessling, C. Christian Johansson, Regulatory T Cells in Cancer Advances in Cancer Research. ,vol. 107, pp. 57- 117 ,(2010) , 10.1016/S0065-230X(10)07003-X
R H Medema, A M de Vries-Smits, G C van der Zon, J A Maassen, J L Bos, Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras. Molecular and Cellular Biology. ,vol. 13, pp. 155- 162 ,(1993) , 10.1128/MCB.13.1.155
C.W. SUGNET, W.J. KENT, M. ARES, D. HAUSSLER, Transcriptome and genome conservation of alternative splicing events in humans and mice. pacific symposium on biocomputing. pp. 66- 77 ,(2003) , 10.1142/9789812704856_0007
Jean Paul Thiery, Hervé Acloque, Ruby Y.J. Huang, M. Angela Nieto, Epithelial-Mesenchymal Transitions in Development and Disease Cell. ,vol. 139, pp. 871- 890 ,(2009) , 10.1016/J.CELL.2009.11.007
JILL L. REITER, NITA J. MAIHLE, Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta. Annals of the New York Academy of Sciences. ,vol. 995, pp. 39- 47 ,(2003) , 10.1111/J.1749-6632.2003.TB03208.X