The antimicrobial peptides lactoferricin B and magainin 2 cross over the bacterial cytoplasmic membrane and reside in the cytoplasm.
作者： H.H. Haukland , H. Ulvatne , K. Sandvik , L.H. Vorland
DOI: 10.1016/S0014-5793(01)03100-3
关键词: Microbiology 、 Antimicrobial peptides 、 Cecropin 、 Lactoferricin 、 Magainin 、 Staphylococcus aureus 、 Bacteria 、 Cytoplasm 、 Biology 、 Escherichia coli
摘要: The localization of immunolabelled antimicrobial peptides was studied using transmission electron microscopy. Staphylococcus aureus and Escherichia coli were exposed to lactoferricin B (17–41), (17–31) D-lactoferricin (17–31). E. also cecropin P1 magainin 2. lactoferricins found in the cytoplasm both bacteria. In S. amount cytoplasmic (17–41) time- concentration-dependent, reaching a maximum within 30 min. Cecropin confined cell wall, while 2 coli. finding intracellularly localized is not reported previously.
elsevier.com
sci-hub.se 参考文章(21)
H G Boman, B Agerberth, A Boman, Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infection and Immunity. ,vol. 61, pp. 2978- 2984 ,(1993) , 10.1128/IAI.61.7.2978-2984.1993
C. B. Park, K.-S. Yi, K. Matsuzaki, M. S. Kim, S. C. Kim, Structure–activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: The proline hinge is responsible for the cell-penetrating ability of buforin II Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 8245- 8250 ,(2000) , 10.1073/PNAS.150518097
O. Aguilera, H. Ostolaza, L.M. Quirós, J.F. Fierro, Permeabilizing action of an antimicrobial lactoferricin‐derived peptide on bacterial and artificial membranes FEBS Letters. ,vol. 462, pp. 273- 277 ,(1999) , 10.1016/S0014-5793(99)01545-8
D. Wade, A. Boman, B. Wahlin, C. M. Drain, D. Andreu, H. G. Boman, R. B. Merrifield, All-D amino acid-containing channel-forming antibiotic peptides. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 4761- 4765 ,(1990) , 10.1073/PNAS.87.12.4761
W. Bellamy, M. Takase, H. Wakabayashi, K. Kawase, M. Tomita, Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin Journal of Applied Microbiology. ,vol. 73, pp. 472- 479 ,(1992) , 10.1111/J.1365-2672.1992.TB05007.X
Chan Bae Park, Hun Sik Kim, Sun Chang Kim, Mechanism of Action of the Antimicrobial Peptide Buforin II: Buforin II Kills Microorganisms by Penetrating the Cell Membrane and Inhibiting Cellular Functions Biochemical and Biophysical Research Communications. ,vol. 244, pp. 253- 257 ,(1998) , 10.1006/BBRC.1998.8159
Ehud Gazit, Anita Boman, Hans G. Boman, Yechiel Shai, Interaction of the mammalian antibacterial peptide cecropin P1 with phospholipid vesicles. Biochemistry. ,vol. 34, pp. 11479- 11488 ,(1995) , 10.1021/BI00036A021
Manhong Wu, Elke Maier, Roland Benz, Robert E. W. Hancock, Mechanism of Interaction of Different Classes of Cationic Antimicrobial Peptides with Planar Bilayers and with the Cytoplasmic Membrane of Escherichia coli Biochemistry. ,vol. 38, pp. 7235- 7242 ,(1999) , 10.1021/BI9826299
Katsumi Matsuzaki, Magainins as paradigm for the mode of action of pore forming polypeptides Biochimica et Biophysica Acta. ,vol. 1376, pp. 391- 400 ,(1998) , 10.1016/S0304-4157(98)00014-8
Chilukuri Subbalakshmi, Narasimhaiah Sitaram, Mechanism of antimicrobial action of indolicidin Fems Microbiology Letters. ,vol. 160, pp. 91- 96 ,(1998) , 10.1111/J.1574-6968.1998.TB12896.X