The role of corticotropin-releasing factor in depression and anxiety disorders

作者: L Arborelius , MJ Owens , PM Plotsky , CB Nemeroff

DOI: 10.1677/JOE.0.1600001

关键词: Internal medicineEndocrinologyAppetitePremovement neuronal activityMaternal deprivationCorticotropin-releasing hormoneAntidepressantAnxietyDepression (differential diagnoses)MedicineAnxiety disorder

摘要: Sustained stimulation of G-protein-coupled receptors (GPCRs) typically causes receptor desensitisation, which is mediated by phosphorylation, often within the C-terminal tail of the …

参考文章(91)
Andrew F. Pitts, Stephen D. Samuelson, William H. Meller, Garth Bissette, Charles B. Nemeroff, Roger G. Kathol, Cerebrospinal fluid corticotropin-releasing hormone, vasopressin, and oxytocin concentrations in treated patients with major depression and controls Biological Psychiatry. ,vol. 38, pp. 330- 335 ,(1995) , 10.1016/0006-3223(95)00229-A
Constance Hammen, Michael Gitlin, Joanne Davila, Aimee Ellicott, Gary Brown, Psychiatric history and stress: predictors of severity of unipolar depression. Journal of Abnormal Psychology. ,vol. 101, pp. 45- 52 ,(1992) , 10.1037//0021-843X.101.1.45
S.C Heinrichs, J Lapsansky, T.W Lovenberg, E.B De Souza, D.T Chalmers, Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior Regulatory Peptides. ,vol. 71, pp. 15- 21 ,(1997) , 10.1016/S0167-0115(97)01005-7
Mitchel A. Kling, David R. Rubinow, Allen R. Doran, Alec Roy, Candace L. Davis, Joseph R. Calabrese, Lynnette K. Nieman, Robert M. Post, George P. Chrousos, Philip W. Gold, Cerebrospinal fluid immunoreactive somatostatin concentrations in patients with cushing’s disease and major depression: Relationship to indices of corticotropin-releasing hormone and cortisol secretion Neuroendocrinology. ,vol. 57, pp. 79- 88 ,(1993) , 10.1159/000126345
C O Ladd, M J Owens, C B Nemeroff, Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation Endocrinology. ,vol. 137, pp. 1212- 1218 ,(1996) , 10.1210/ENDO.137.4.8625891
CLAIRE-DOMINIQUE WALKER, MARILYN PERRIN, WYLIE VALE, CATHERINE RIVIER, Ontogeny of the stress response in the rat: role of the pituitary and the hypothalamus. Endocrinology. ,vol. 118, pp. 1445- 1451 ,(1986) , 10.1210/ENDO-118-4-1445
George W Smith, Jean-Michel Aubry, Francoise Dellu, Angelo Contarino, Louise M Bilezikjian, Lisa H Gold, Ruoping Chen, Yelena Marchuk, Chris Hauser, Cornelia A Bentley, Paul E Sawchenko, George F Koob, Wylie Vale, Kuo-Fen Lee, Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. ,vol. 20, pp. 1093- 1102 ,(1998) , 10.1016/S0896-6273(00)80491-2
Erik Widerlöv, Garth Bissette, Charles B. Nemeroff, Monoamine metabolites, corticotropin releasing factor and somatostatin as CSF markers in depressed patients Journal of Affective Disorders. ,vol. 14, pp. 99- 107 ,(1988) , 10.1016/0165-0327(88)90051-1
S. LEVINE, D. M. LYONS, A. F. SCHATZBERG, Psychobiological Consequences of Social Relationships Annals of the New York Academy of Sciences. ,vol. 807, pp. 210- 218 ,(1997) , 10.1111/J.1749-6632.1997.TB51922.X