Removal of dental alloys and titanium attenuates trace metals and biological effects on liver and kidney.
作者： Yu Pan , Yunzhi Lin , Lei Jiang , Honglei Lin , Caiming Xu
DOI: 10.1016/J.CHEMOSPHERE.2019.125205
关键词: Kidney 、 Chemistry 、 Biocompatibility 、 Histopathology 、 Alloy 、 Apoptosis 、 Titanium 、 Trace metal 、 Endocrinology 、 Internal medicine 、 Cheek pouch
摘要: Abstract To determine whether the potential effects on liver and kidney caused by dental alloys could be reduced or terminated removal of nickel-chromium (Ni-Cr) alloy, cobalt-chromium (Co-Cr) commercially pure titanium (CP-Ti), they were placed in cheek pouches Syrian hamsters according to ISO 10993-10. Then, peak/plateau end times trace metals blood determined with without alloys. Based these time points, their examined. We found that released from accumulated transiently blood, liver, but had no effect histopathology kidney. Although functions compromised, function tissues seemed clinically acceptable compared those control hamsters. In addition, apoptotic renal cells was removing Ni-Cr Co-Cr alloys, hepatocytes also eliminated alloy. contrast, alloy temporary recovered itself. Taken together, Ni- Co-based have Moreover, induce transient metal accumulation kidney, which can while CP-Ti shows favorable biocompatibility.
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