A JAK/STAT-MEDIATED INFLAMMATORY SIGNALING CASCADE DRIVES ONCOGENESIS IN AF10-REARRANGED AML.
作者： Robert J. Wechsler-Reya , Torsten Haferlach , Soheil Meshinchi , Connie J. Eaves , Irmela Jeremias
关键词: Epigenomics 、 Carcinogenesis 、 stat 、 Gene regulatory network 、 Cancer research 、 JAK-STAT signaling pathway 、 Fusion protein 、 PICALM 、 KMT2A 、 Biology
摘要: … , we generated inducible mouse models of acute myeloid leukemia (AML) driven by the most … in mouse and human models of AF10 fusion AML. Collectively, our study identifies JAK1 as …
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