The role of inflammation in early and late venous thrombosis: Are there clinical implications?

摘要: Venous thrombosis is associated with a significant inflammatory response. Inflammatory cells, adhesion molecules (especially selectins), cytokines, and procoagulant microparticles appear to be the thrombogenic process. Once thrombus forms, cells are important resolution along fibrinolytic agents proinflammatory mediators. Collagen elastin breakdown by DVT renders vein wall stiff non-compliant. Rapid complete should lessen damage or prevent development of chronic venous insufficiency. Understanding basic biology thrombogenesis important, as novel therapies both treat hasten result from better understanding biological mechanisms.