Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands.
作者： Fotini Naoum , Konstantinos Kasiotis , Prokopios Magiatis , Serkos Haroutounian
DOI: 10.3390/12071259
关键词: Substituent 、 Ring (chemistry) 、 Estrogen receptor beta 、 Pyrazole 、 Estrogen receptor 、 Chemistry 、 Nitro 、 Stereochemistry
摘要: Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and binding affinity towards the estrogen receptor (ER) subtypes ERα ERβ was determined. Among compounds tested, 2-nitrophenol derivative 5c found to bind satisfactorily both (RBAα=5.17 RBAβ=3.27). In general, introduction of group into A these benefit abilities.
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