Understanding the Effects of Kidney Disease and Dialysis Treatment on Pharmacotherapy in Children.
作者： Verena Gotta , Olivera Marsenic , Marc Pfister
DOI: 10.1007/164_2019_224
关键词: Intensive care medicine 、 Dialysis 、 Hemofiltration 、 Medicine 、 Acute kidney injury 、 Hemodialysis 、 Peritoneal dialysis 、 Renal replacement therapy 、 Pharmacotherapy 、 Kidney disease
摘要: Chronic kidney disease (CKD) and acute injury (AKI) requiring renal replacement therapy (RRT) by dialysis are rare conditions in pediatric patients. In patients with CKD, is mainly performed using peritoneal (PD) or intermittent hemodialysis (HD). AKI, continuous (CRRT) hemofiltration, hemodialysis, both techniques can be used. This chapter reviews (1) physiology epidemiology of children (2) pharmacokinetic principles to considered for developing dose recommendations under different modalities. Methods calculating predicting drug clearance reviewed; scaling approaches from data obtained adults discussed.
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