A multicenter study of the influence of fat and lean mass on bone mineral content: evidence for differences in their relative influence at major fracture sites. Early Postmenopausal Intervention Cohort (EPIC) Study Group.
作者： M M Hla , J W Davis , P D Ross , R D Wasnich , A J Yates
关键词: Medicine 、 Animal science 、 Fracture site 、 Surgery 、 Lean body mass 、 Cohort 、 Bone mineral content 、 Adipose tissue 、 Skeleton (computer programming) 、 Bone density 、 Interquartile range
摘要: We examined the relative influence of fat and lean mass on bone mineral content (BMC) among 1600 early postmenopausal women aged 45-59 y from four geographical locations (Nottingham, United Kingdom; Portland, OR; Honolulu; Copenhagen). Bone sites investigated included major fracture sites: hip, spine, radius. Body weight had strong associations at all skeletal (BMC differences 4-6% per interquartile range (IQR) weight). Associations with components were more variable. The BMC IQR 5-7% hip sites, 3% 2% radial sites. greater for may reflect high physical mobility muscular activity this site. 4% 5% ultradistal These results suggest that low or mass, particularly extremes, adversely affect greatest most highly trabecular With only a few exceptions, similar in direction comparable magnitude across geographic locations. conclude both have independent influences but their vary by site depending content, mobility, muscularity Am J
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