Molecular and Cellular Biology of the Blood-Brain Barrier and Its Characteristics in Brain Tumors

作者: Helga E. Vries , Lisette Montagne , Christine D. Dijkstra , Paul Valk

DOI: 10.1385/1-59259-843-9:157

关键词: Vascular endothelial growth factorTight junctionBiologyGliomaCentral nervous systemBrain tumorBlood–brain barrierCell biology

摘要: The inner milieu of the central nervous system (CNS) is closely regulated by blood-brain barrier (BBB). By its unique properties, BBB restricts entrance blood-borne large and hydrophilic compounds into brain, but also tightly controls cellular entry supply nutrients to brain. In this chapter, we will address latest advances in both molecular biology specialized structure, discuss functional characteristics organization glioma.

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