Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

摘要: Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system, being expressed in neurons and non-neuronal cells, where they participate a variety of physiological responses like memory, learning, locomotion, attention, among others. We will focus on α7 nAChR subtype, which has been implicated neuroprotection, synaptic plasticity neuronal survival, is considered as potential therapeutic target for several neurological diseases. Oxidative stress neuroinflammation currently two most important pathological mechanisms common neurodegenerative diseases such Alzheimer, Parkinson or Huntington In this review, we first analysed distribution expression mammalian brain. Then, focused function subtype cells its role immune (cholinergic anti-inflammatory pathway). Finally, revise pathway promoted via activation that related to recruitment Jak2/STAT3 pathway, one hand inhibits NF-κB nuclear translocation, other hand, activates master regulator oxidative Nrf2/HO-1. This review provides profound insight into microglia point out microglial α7/HO-1 an target.