Endothelial healing following defined injury to rabbit aorta. Depth of injury and mode of repair.
作者： L.N. Walker , M.M. Ramsay , D.E. Bowyer
DOI: 10.1016/0021-9150(83)90149-1
关键词: Endothelium 、 Medicine 、 Aorta 、 Aortic endothelium 、 Anatomy 、 Platelet aggregation 、 Wound healing 、 Platelet 、 Cell adhesion 、 Rabbit aorta
摘要: A study has been made of the healing a narrow deep injury to rabbit aortic endothelium which also involves damage media vessel. The was produced using nylon catheter containing wire filament; approximately 150 micron in width and damaged up 3 elastic lamellae. Immediately after platelet aggregates were observed over injured areas, several hours later large numbers leukocytes seen adhere. Two days non-thrombogenic neointimal surface deeply areas; endothelial cells could be identified covering area at 6 days. process following directly compared with superficial similar width, where are removed without significant vessel [1]. results show that (a) aorta causes aggregation proliferation smooth muscle occurs, (b) despite disruption subendothelial components, rapidly regenerates area, although not as quickly for injury.
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