Atomoxetine accelerates attentional set shifting without affecting learning rate in the rat.
作者： Nelson K. Totah , Nikos K. Logothetis , Oxana Eschenko
DOI: 10.1007/S00213-015-4028-5
关键词: Schizophrenia 、 Atomoxetine 、 Attentional set 、 Prefrontal cortex 、 Flexibility (personality) 、 Psychology 、 Reuptake inhibitor 、 Cognitive flexibility 、 Cognitive psychology 、 Neuroscience 、 Task (project management)
摘要: Shifting to a new rule is form of behavioral flexibility that impaired in numerous psychiatric and neurological illnesses. Animal studies have revealed this depends upon norepinephrine (NE) neurotransmission. Atomoxetine, NE reuptake inhibitor, improves performance humans set shifting tasks. Our objective was validate its effects rodent task. We tested the drug effect using an operant task required shift from visual cue-guided behavior novel location-guided rule. A 1.0-mg/kg dose significantly accelerated without affecting learning strategies, such as win-stay or lose-shift. Fitting with function provided measure rate. This analysis atomoxetine
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