Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma.

摘要: Airway expression of monocyte chemotactic protein-4 (MCP-4; CCL-13) is known to be increased in asthmatic airways where it induced by proallergic cytokines, but the relationship its systemic asthma and naturally occurring exacerbations unknown. We determined plasma levels MCP-4 356 individuals with chronic-stable 240 normal subjects compared 30 patients who presented for emergent treatment 90 matched age, gender, ethnicity. Median were higher than (399 vs. 307 pg/mL) (p 218 pg/mL at risk < 0.001 odds ratio, 3.26; 95% CI, 2.22-4.79). Logistic regression identified as an independent predictor diagnosis. The are acute exacerbation (513 355 = 0.002). a systemically expressed biomarker that independently predicts susceptibility directly associated exacerbations. Elevated identify group asthmatics evidence allergic inflammation may or benefit from abrogation MCP-4.