Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: a systematic review and meta-analysis

摘要: Summary. Paracetamol is the most commonly prescribed analgesic for treatment of acute pain. The efficacy and safety i.v. formulations paracetamol unclear. We performed a systematic search (multiple databases, bibliographies, any language, to May 2010) single-dose, randomized, controlled clinical trials propacetamol or postoperative pain in adults children. Thirty-six studies involving 3896 patients were included. For primary outcome, 37% (240/367) receiving experienced at least 50% relief over 4 h compared with 16% (68/527) placebo (number needed treat¼4.0; 95% confidence interval, 3.5–4.8). proportion groups experiencing diminished 6 h. Patients required 30% less opioid than those placebo. However, this did not translate reduction opioid-induced adverse events (AEs). Similar comparisons between active comparators either statistically significant, clinically both. AEs occurred similar rates on infusion more frequently (23% vs 1%). A single dose provides around effective analgesia about Both are associated few AEs, although have higher incidence infusion.