The Caspase 8 Inhibitor c-FLIPL Modulates T-Cell Receptor-Induced Proliferation but Not Activation-Induced Cell Death of Lymphocytes
作者： Susanne M. A. Lens , Takao Kataoka , Karen A. Fortner , Antoine Tinel , Isabel Ferrero
DOI: 10.1128/MCB.22.15.5419-5433.2002
关键词: Caspase 8 、 Molecular biology 、 Cell biology 、 Biology 、 Apoptosis 、 Cytotoxic T cell 、 Programmed cell death 、 Caspase 、 Interleukin 2 、 CD8 、 Fas receptor
摘要: The caspase 8 inhibitor c-FLIP(L) can act in vitro as a molecular switch between cell death and growth signals transmitted by the receptor Fas (CD95). To elucidate its function vivo, transgenic mice were generated that overexpress T-cell compartment (c-FLIP(L) Tg mice). As anticipated, FasL-induced apoptosis was inhibited T cells from mice. In contrast, activation-induced of unaffected, suggesting this deletion process proceed absence active 8. Accordingly, differed Fas-deficient showing no accumulation B220(+) CD4(-) CD8(-) cells. However, stimulation lymphocytes with suboptimal doses anti-CD3 or antigen revealed increased proliferative responses Thus, major role vivo is modulation proliferation decreasing signaling threshold.
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