Neurocognitive profile in psychotic versus nonpsychotic individuals with 22q11.2 deletion syndrome

摘要: Abstract The 22q11.2 deletion syndrome (22q11DS) is associated with increased rates of psychotic disorders and cognitive deficits, but large scale studies are needed to elucidate their interaction. objective this two-center study was identify the neurocognitive phenotype individuals 22q11DS disorders. We hypothesized that compared nonpsychotic deleted would have more severe especially in executive function social cognition. These deficits be present when IQ- matched Williams Syndrome (WS). Three groups were ascertained from Tel Aviv Philadelphia centers: a disorder ( n =31), =86) typically-developing controls (TD, =828). In group WS =18) IQ also included. Penn Computerized Neurocognitive Battery (CNB) used assess wide-range functions all patients underwent structured psychiatric evaluations. performed poorly on CNB domains TD. Participants psychosis, 22q11DS, had global performance (GNP), function, cognition episodic memory domains. primary significant comparing IQ-matched WS. conclusion, specific reliably identified cross nationality using CNB. dysfunctions should further studied as potential endophenotypes psychosis targets for intervention.