Chromosomal aberrations and schizophrenia. Autosomes.

摘要: Chromosomal aberrations associated with schizophrenic disorders may suggest regions in which to focus a search for genes predisposing schizophrenia by linkage strategy. As other genetic illnesses, chromosomal abnormalities also provide useful tools subsequent physical mapping, fine localisation, and isolation of important susceptibility genes. Identification several be especially important, given the unknown pathophysiology, paucity known brain genes, probable heterogeneity manic-depression. However, because psychiatric are common inherited complex manner, researchers must use caution when drawing inferences about associations aberrations. Reported involving autosomes (chromosomes 1-22) psychotic reviewed. Their relevance studies localising was estimated standardised criteria specificity, diagnosis, family history, overall weight evidence. Four 'possibly relevant' were identified: 5q, 11q, 18q, 19p. This paper outlines strategies future detect new major that relevant isolating schizophrenia.