Synthesis and Antimicrobial Activities of His(2-aryl)-Arg and Trp-His(2-aryl) Classes of Dipeptidomimetics
作者： Amit Mahindra , Krishna K. Sharma , Dinesh Rathore , Shabana. I. Khan , Melissa R. Jacob
DOI: 10.1039/C4MD00041B
关键词: Drug 、 Biochemistry 、 Bioinformatics 、 Peptidomimetic 、 Antimicrobial 、 Amphotericin B 、 Aryl 、 Cytotoxicity 、 Staphylococcus aureus 、 Medicine 、 In vitro
摘要: In this communication, we report the design, synthesis and in vitro antimicrobial activity of ultra short peptidomimetics. Besides producing promising antibacterial activities against Staphylococcus aureus methicillin-resistant S. (MRSA), dipeptidomimetics exhibited high antifungal C. neoformans with IC50 values range 0.16–19 μg mL−1. The most potent analogs 4-fold higher than currently used drug amphotericin B, no apparent cytotoxicity a panel mammalian cell lines.
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