Treating inflammation with the Janus Kinase inhibitor CP-690,550

作者: Lalitha Vijayakrishnan , R. Venkataramanan , Palak Gulati

DOI: 10.1016/J.TIPS.2010.10.004

关键词: Signal transductionImmunosuppressionJanus kinase inhibitorTyrosine kinaseInflammationBiologyJanus kinase 3Transplant rejectionPharmacologyImmune system

摘要: … This unusual structure gives this kinase family the name ‘Janus’ (after the Roman god who was most often depicted with two faces). Upon interaction between a cytokine and a cytokine …

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