Preparation of enantiomerically pure (R)-2-butyryloxymethylglycidol by lipase-catalyzed asymmetric hydrolysis
作者： Young-Bae Seu , Taeg-Kyeong Lim , Chang-Jin Kim , Sun-Chul Kang
DOI: 10.1016/0957-4166(95)00397-5
关键词: Yield (chemistry) 、 Hydrolysis 、 Lipase 、 Epoxy 、 Optically active 、 Enantiomer 、 Alcohol 、 Organic chemistry 、 Chemistry 、 Catalysis
摘要: Abstract Optically active epoxy alcohol, (R)-2-butyryloxymethylglycidol3 which is the precursor of a tert-alcohol chiral building block was obtained in high enantiomeric purity, 98.7% e.e., by lipase-catalyzed asymmetric hydrolysis using phosphate buffer and organic co-solvent system 95% chemical yield.
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