Combination therapy with an anti-hyaluronan agent and therapeutic agent
作者： H. Michael Shepard , Daniel C. Maneval , Curtis B. Thompson
DOI:
关键词: Nucleoside 、 Combination therapy 、 Solid tumor 、 Medicine 、 Taxane 、 Pharmacology 、 Enzyme
摘要: Provided herein is combination therapy containing an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme, and tumor-targeted taxane, optionally further chemotherapeutic agent nucleoside analog. The can be used in methods of treating cancers, particular solid tumor cancers.
lens.org参考文章(419)
Miren J. Omaetxebarria, Felix Elortza, Eva Rodríguez-Suárez, Kerman Aloria, Jesus M. Arizmendi, Ole N. Jensen, Rune Matthiesen, Computational approach for identification and characterization of GPI‐anchored peptides in proteomics experiments Proteomics. ,vol. 7, pp. 1951- 1960 ,(2007) , 10.1002/PMIC.200700068
Frank Pedi, Benjamin Oshlack, Mark Chasin, Controlled release formulations coated with aqueous dispersions of acrylic polymers ,(1994)
Minoru Okayama, Kayoko Oguri, Koji Kimata, Motoo Hozumi, Yoshio Honma, Sakaru Suzuki, Increased synthesis of hyaluronic acid by mouse mammary carcinoma cell variants with high metastatic potential. Cancer Research. ,vol. 43, pp. 1347- 1354 ,(1983)
Louis Bookbinder, Ge Wei, Gregory I. Frost, Krishnasamy Panneerselvam, Extended soluble ph20 polypeptides and uses thereof ,(2009)
R Krumlauf, R E Hammer, S M Tilghman, R L Brinster, Developmental regulation of α-fetoprotein genes in transgenic mice Molecular and Cellular Biology. ,vol. 5, pp. 1639- 1648 ,(1985) , 10.1128/MCB.5.7.1639
Antoni Kozlowski, J. Milton Harris, Poly(Ethylene Glycol) Derivatives with Proximal Reactive Groups ,(1999)
Maarten J. Krupers, Fred J. Van Der Gaag, Jan Feijen, Complexation of poly(ethylene oxide) with poly(acrylic acid-co-hydroxyethyl methacrylate)s European Polymer Journal. ,vol. 32, pp. 785- 790 ,(1996) , 10.1016/0014-3057(95)00184-0
YI-AN LU, ARTHUR M. FELIX, Pegylated peptides. II. Solid-phase synthesis of amino-, carboxy- and side-chain pegylated peptides. International Journal of Peptide and Protein Research. ,vol. 43, pp. 127- 138 ,(2009) , 10.1111/J.1399-3011.1994.TB00513.X
Neil P. Desai, Patrick Soon-Shiong, Methods of treatment of pancreatic cancer ,(2011)
Michael A Jacobetz, Derek S Chan, Albrecht Neesse, Tashinga E Bapiro, Natalie Cook, Kristopher K Frese, Christine Feig, Tomoaki Nakagawa, Meredith E Caldwell, Heather I Zecchini, Martijn P Lolkema, Ping Jiang, Anne Kultti, Curtis B Thompson, Daniel C Maneval, Duncan I Jodrell, Gregory I Frost, H M Shepard, Jeremy N Skepper, David A Tuveson, Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer Gut. ,vol. 62, pp. 112- 120 ,(2013) , 10.1136/GUTJNL-2012-302529