Hepatocellular carcinoma in chronic hepatitis C: from bench to bedside.

摘要: Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and seventh women, accounting for 7 % of all cancers, third cause cancer-related death worldwide. Nearly 90 to 95 HCC occur context known often preventable risk factors, such as chronic viral hepatitis, alcohol abuse, metabolic disorders. Although several experimental lines research support a direct role hepatitis C virus (HCV) promotion, cirrhosis main factor this tumor, whereas other factors like tobacco smoking are clearly able accelerate development. For reason, cirrhotic patients with HCV infection subjected abdominal ultrasound surveillance every 6 months, aimed at an early diagnosis allow curative treatment options. Current strategies positively impact on incidence rates include prevention development by avoiding metabolic, pharmacological, or social associated accelerated progression liver disease, through eradication interferon-based treatments. Moreover, successful antiviral has added benefit impacting rate also who already cirrhotic.