Landscape and variation of RNA secondary structure across the human transcriptome

作者: Yue Wan , Kun Qu , Qiangfeng Cliff Zhang , Ryan A. Flynn , Ohad Manor

DOI: 10.1038/NATURE12946

关键词: RNA editingNucleic acid secondary structureIntronNon-coding RNAExonGenetics5.8S ribosomal RNARNAPost-transcriptional modificationBiology

摘要: In parallel to the genetic code for protein synthesis, a second layer of information is embedded in all RNA transcripts in the form of RNA structure. RNA structure influences practically …

参考文章(26)
Yoseph Barash, John A. Calarco, Weijun Gao, Qun Pan, Xinchen Wang, Ofer Shai, Benjamin J. Blencowe, Brendan J. Frey, Deciphering the splicing code Nature. ,vol. 465, pp. 53- 59 ,(2010) , 10.1038/NATURE09000
Robert C Spitale, Pete Crisalli, Ryan A Flynn, Eduardo A Torre, Eric T Kool, Howard Y Chang, RNA SHAPE analysis in living cells Nature Chemical Biology. ,vol. 9, pp. 18- 20 ,(2013) , 10.1038/NCHEMBIO.1131
Michael Kertesz, Yue Wan, Elad Mazor, John L. Rinn, Robert C. Nutter, Howard Y. Chang, Eran Segal, Genome-wide measurement of RNA secondary structure in yeast Nature. ,vol. 467, pp. 103- 107 ,(2010) , 10.1038/NATURE09322
TIH Project, None, The International HapMap Project Nature. ,vol. 426, pp. 789- 796 ,(2003) , 10.1038/NATURE02168
Andrew Grimson, Kyle Kai-How Farh, Wendy K. Johnston, Philip Garrett-Engele, Lee P. Lim, David P. Bartel, MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Molecular Cell. ,vol. 27, pp. 91- 105 ,(2007) , 10.1016/J.MOLCEL.2007.06.017
Melissa L Wilbert, Stephanie C Huelga, Katannya Kapeli, Thomas J Stark, Tiffany Y Liang, Stella X Chen, Bernice Y Yan, Jason L Nathanson, Kasey R Hutt, Michael T Lovci, Hilal Kazan, Anthony Q Vu, Katlin B Massirer, Quaid Morris, Shawn Hoon, Gene W Yeo, None, LIN28 Binds Messenger RNAs at GGAGA Motifs and Regulates Splicing Factor Abundance Molecular Cell. ,vol. 48, pp. 195- 206 ,(2012) , 10.1016/J.MOLCEL.2012.08.004
Matthew Halvorsen, Joshua S. Martin, Sam Broadaway, Alain Laederach, Disease-Associated Mutations That Alter the RNA Structural Ensemble PLOS Genetics. ,vol. 6, ,(2010) , 10.1371/JOURNAL.PGEN.1001074
Benjamin P. Lewis, Christopher B. Burge, David P. Bartel, Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell. ,vol. 120, pp. 15- 20 ,(2005) , 10.1016/J.CELL.2004.12.035
Yue Wan, Michael Kertesz, Robert C. Spitale, Eran Segal, Howard Y. Chang, Understanding the transcriptome through RNA structure Nature Reviews Genetics. ,vol. 12, pp. 641- 655 ,(2011) , 10.1038/NRG3049