Nitric oxide signaling in the nervous system.
作者： Jay E. Brenman , David S. Bredt
DOI: 10.1016/S0076-6879(96)69014-4
关键词: Nervous system 、 Nitric oxide 、 Central nervous system 、 Endocrinology 、 Postsynaptic potential 、 Retrograde signaling 、 Cell biology 、 Biology 、 Signal transduction 、 Cyclic guanosine monophosphate 、 Transduction (physiology) 、 Internal medicine
摘要: Publisher Summary This chapter discusses the nitric oxide (NO) signaling in nervous system. The unstable guanylyl cyclase activator has properties similar to that of endothelial-derived relaxing factor, which is demonstrated be NO. role for NO brain shows synthase (NOS) inhibitors, such as L -monomethylarginine, potently block glutamate-mediated stimulation cyclic guanosine monophosphate (cGMP) levels cerebellar slices. enrichment and cGMP transduction pathways cerebellum motivate initial characterization NOS from this region. Physiological roles central system (CNS) are suggested by discrete highly conserved distribution subpopulations neurons all mammalian brains examined. Synaptic functions implied biochemical electron micrographic studies indicate at subcellular level, enriched pre- postsynaptic junctions. unique capacity function a rapidly diffusible messenger suggests possible mediating certain actions require fast-acting retrograde messenger.
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