High-dose idarubicin in combination with Ara-C in patients with relapsed or refractory acute lymphoblastic leukemia: a pharmacokinetic and clinical study
作者： Alessandra Tedeschi , Marco Montillo , Elena Strocchi , Anna Maria Cafro , Elisabetta Tresoldi
DOI: 10.1007/S00280-006-0332-4
关键词: Medicine 、 Refractory 、 Acute lymphocytic leukemia 、 Cerebrospinal fluid 、 Idarubicin 、 Pharmacology 、 Metabolite 、 Cytarabine 、 Pharmacokinetics 、 Antimetabolite
摘要: Objective High dose (HD) Ara-C combined with a single HD idarubicin (IDA) is an efficient and safe salvage regimen for patients refractory or relapsed acute lymphoblastic leukemia as indicated by phase II studies. No data are available on the pharmacokinetics of IDA after rapid intravenous infusion. An open pharmacokinetic clinical study was performed to evaluate antileukemic efficacy, investigate presence its reduced metabolite idarubicinol (IDAol) in cerebrospinal fluid (CSF) treated HD-IDA.
springer.com
sci-hub.se 参考文章(32)
R Schnell, K Hübel, P Borchmann, A Engert, Idarubicin: a brief overview on pharmacology and clinical use. International Journal of Clinical Pharmacology and Therapeutics. ,vol. 35, pp. 80- 83 ,(1997)
Capizzi Rl, Capizzi Rl, Richards F nd, Richards F nd, Cooper Mr, Spurr Cl, Spurr Cl, White Dr, White Dr, Jackson Dv, Jackson Dv, Poole M, Poole M, Muss Hb, Muss Hb, Stuart Jj, Stuart Jj, Hopkins Jo, Hopkins Jo, Treatment of poor risk acute leukemia with sequential high-dose ARA-C and asparaginase Blood. ,vol. 63, pp. 694- 700 ,(1984) , 10.1182/BLOOD.V63.3.694.694
Weiss Ma, Treatment of adult patients with relapsed or refractory acute lymphoblastic leukemia (ALL). Leukemia. ,vol. 11, ,(1997)
Mark D. Krailo, Thomas W. Pendergrass, Joel M. Reid, Matthew M. Ames, G. Denman Hammond, Plasma Pharmacokinetics and Cerebrospinal Fluid Concentrations of Idarubicin and Idarubicinol in Pediatric Leukemia Patients: A Childrens Cancer Study Group Report Cancer Research. ,vol. 50, pp. 6525- 6528 ,(1990)
Fiorina Giona, Luciana Annino, Roberto Rondelli, William Arcese, Giovanna Meloni, Anna Maria Testi, Maria Luisa Moleti, Sergio Amadori, Luigi Resegotti, Antonio Tabilio, Saverio Ladogana, Giuseppe Fioritoni, Andrea Camera, Vincenzo Liso, Pietro Leoni, Franco Mandelli, Treatment of adults with acute lymphoblastic leukaemia in first bone marrow relapse : results of the ALL R-87 protocol British Journal of Haematology. ,vol. 97, pp. 896- 903 ,(1997) , 10.1046/J.1365-2141.1997.1102926.X
Anna Maria Testi, Ilaria Del Giudice, William Arcese, Maria Luisa Moleti, Fiorina Giona, Giuseppe Basso, Andrea Biondi, Valentino Conter, Chiara Messina, Roberto Rondelli, Alessandra Micozzi, Concetta Micalizzi, Elena Barisone, Franco Locatelli, Giorgio Dini, Maurizio Arico, Fiorina Casale, Margherita Comis, Saverio Ladogana, Alma Lippi, Rossella Mura, Marie France Pinta, Nicola Santoro, Maria Grazia Valsecchi, Giuseppe Masera, Franco Mandelli, None, A single high dose of idarubicin combined with high-dose ARA-C for treatment of first relapse in childhood 'high-risk' acute lymphoblastic leukaemia: a study of the AIEOP group British Journal of Haematology. ,vol. 118, pp. 741- 747 ,(2002) , 10.1046/J.1365-2141.2002.03706.X
Kirsten J.M Schimmel, Dick J Richel, Renée B.A van den Brink, Henk-Jan Guchelaar, Cardiotoxicity of cytotoxic drugs. Cancer Treatment Reviews. ,vol. 30, pp. 181- 191 ,(2004) , 10.1016/J.CTRV.2003.07.003
Samer Suki, Hagop Kantarjian, Varsha Gandhi, Elihu Estey, Susan O'Brien, Miloslav Beran, Mary Beth Rios, William Plunkett, Michael Keating, Fludarabine and cytosine arabinoside in the treatment of refractory or relapsed acute lymphocytic leukemia. Cancer. ,vol. 72, pp. 2155- 2160 ,(1993) , 10.1002/1097-0142(19931001)72:7<2155::AID-CNCR2820720715>3.0.CO;2-V
Deborah A. Thomas, Hagop Kantarjian, Terry L. Smith, Charles Koller, Jorge Cortes, Susan O'Brien, Francis J. Giles, James Gajewski, Sherry Pierce, Michael J. Keating, Primary refractory and relapsed adult acute lymphoblastic leukemia: characteristics, treatment results, and prognosis with salvage therapy. Cancer. ,vol. 86, pp. 1216- 1230 ,(1999) , 10.1002/(SICI)1097-0142(19991001)86:7<1216::AID-CNCR17>3.0.CO;2-O
Nicola Gokbuget, Dieter Hoelzer, Renate Arnold, Angelika Böhme, Claus R. Bartram, Matthias Freund, Arnold Ganser, Michael Kneba, Werner Langer, Thomas Lipp, Wolf-Dieter Ludwig, Georg Maschmeyer, Harald Rieder, Eckhard Thiel, Adelheid Weiss, Dorle Messerer, Treatment of Adult ALL According to Protocols of the German Multicenter Study Group for Adult ALL (GMALL) Hematology-oncology Clinics of North America. ,vol. 14, pp. 1307- 1325 ,(2000) , 10.1016/S0889-8588(05)70188-X