Increased gene expression of growth associated protein-43 in skin of patients with early-stage peripheral neuropathies
作者： Sarah Scheytt , Nadja Riediger , Silvia Braunsdorf , Claudia Sommer , Nurcan Üçeyler
DOI: 10.1016/J.JNS.2015.05.044
关键词: Medicine 、 Gene expression 、 Peripheral 、 Gap-43 protein 、 Gene product 、 Pathology 、 Nerve fiber 、 Peripheral neuropathy 、 Nerve injury 、 Antibody 、 Neurology 、 Clinical neurology
摘要: Abstract Growth associated protein-43 (GAP-43) is one of the neural proteins with nerve injury that upregulated after injury. To investigate whether GAP-43 quantification in skin biopsies would differentiate subtypes peripheral neuropathies, we analyzed expression from lateral thigh and distal leg. We prospectively enrolled 130 patients neuropathies compared data healthy controls. Intraepidermal fiber density (IENFD) was determined using antibodies against protein gene product 9.5 (PGP 9.5); anti-GAP-43 were applied to visualize regenerating fibers. PGP qRT-PCR. Patients had a generalized reduction IENFD immunoreactive fibers controls (p
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