Genetically Humanized Animal Models
作者： K. Samuelsson , N. Scheer , I. Wilson , C.R. Wolf , C.J. Henderson
DOI: 10.1016/B978-0-12-409547-2.12376-5
关键词: Drug discovery 、 Drug metabolism 、 Pharmacokinetics 、 Pharmacology 、 Toxicity 、 Knockout mouse 、 Selection (genetic algorithm) 、 Computational biology 、 Biology
摘要: Genetically humanized mice for proteins involved in drug metabolism and toxicity engrafted with human hepatocytes are emerging as promising in vivo models improved prediction of the pharmacokinetic, drug–drug interaction, safety characteristics compounds humans. This is an overview on genetically chimeric liver-humanized mouse models, which illustrated examples their utility studies. The compared to give guidance selection most appropriate model by highlighting advantages disadvantages be carefully considered when used studies discovery development.
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