Fusariocin C, a new cytotoxic substance produced by Fusarium moniliforme.

摘要: A new cytotoxic substance, fusariocin C, was isolated from the culture filtrate of Fasarium moniliforme A-130. Fusariocin C27H28O8, forms pale yellow prisms, melting at 242_??_244°C and has an optical rotation [a]20D-20.6° (c=0.25, CHCl3). The ultraviolet absorption spectrum observed 258 365nm. It to HeLa cell leukemia L 1210 cells, showed some anti-tumor activity in vivo for ascitic form Ehrlich carcinoma. LD50 by intraperitoneal in-jection mice determined be 3.97mg/kg. This compound almost devoid anti-microbial activity.