Brain metabolism as measured with positron emission tomography: Serial assessment in a patient with familial Alzheimer's disease

摘要: This paper presents, for the first time, repeated assessments of cerebral metabolism and neuropsychological competence in early Alzheimer9s disease. Regional metabolic rates glucose were measured with positron emission tomography 18 F-fluoro-2-deoxy-D-glucose on three occasions at 8-month intervals, a 57-year-old man disease 2 1 / years9 duration family history neuropathologically confirmed Data compared mean from 12 healthy men. No differences regional found initial patient scan, whereas second third scans was reduced significantly parietal lobes bilaterally some lobe regions. Memory loss demonstrable but then later scans, other aspects cognitive performance remained within normal limits (Wechsler Adult Intelligence Scale, Boston Naming Test, Two-dimensional Block Construction). The results show that memory can precede measurable reduction disease, reductions may not be accompanied by additional deficits.